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Vascular effects of rapid-acting insulin analogs in the diabetic patient: a review

Author(s): Steve Fordan | Philip Raskin

Journal: Vascular Health and Risk Management ISSN 1176-6344
Volume: 2009; Issue: default; Start page: 225; Date: 2009;
Original page

ABSTRACT
Steve Fordan, Philip RaskinDepartment of Medicine, Division, of Endocrinology, University of Texas, Southwestern Medical Center, Dallas, TX, USAAbstract: The insulin analogs lispro, aspart, and glulisine are the only commercially available rapid-acting insulins to treat diabetes. We review the evidence for treating hyperglycemia, using insulin, and specifically using rapid-acting analogs in diabetic individuals, on the prevention of vascular events. We review the beneficial effects of insulin on the vascular system, which include vasodilation and anti-inflammatory actions. The effects of treating hyperglycemia and intensive blood glucose control on vascular outcomes are reviewed.Keywords: lispro, aspart, glulisine, nitric oxide synthetase, nuclear factor kappa B