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The Use of Convection-Enhanced Delivery with Liposomal Toxins in Neurooncology

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Author(s): Massimo S. Fiandaca | Mitchel S. Berger | Krystof S. Bankiewicz

Journal: Toxins
ISSN 2072-6651

Volume: 3;
Issue: 4;
Start page: 369;
Date: 2011;
Original page

Keywords: blood-brain-barrier | convection-enhanced delivery | diffusion | glioma | liposome | neurooncology

ABSTRACT
Liposomes have long been effective delivery vehicles for transport of toxins to peripheral cancers. The combination of convection-enhanced delivery (CED) with liposomal toxins was originally proposed to circumvent the limited delivery of intravascular liposomes to the central nervous system (CNS) due to the blood-brain-barrier (BBB). CED offers markedly improved distribution of infused therapeutics within the CNS compared to direct injection or via drug eluting polymers, both of which depend on diffusion for parenchymal distribution. This review examines the basis for improved delivery of liposomal toxins via CED within the CNS, and discusses preclinical and clinical experience with these therapeutic techniques. How CED and liposomal technologies may influence future neurooncologic treatments are also considered.