Unexpected Hydrazinolysis Behaviour of 1-Chloro-4-methyl-5H-pyridazino[4,5-b]indole and a Convenient Synthesis of New [1,2,4]-Triazolo[4Ã¢Â€Â™,3Ã¢Â€Â™:1,6]pyridazino[4,5-b]indolesAuthor(s): Hussein El-Kashef | Abdelrahman A. H. Farghaly | Norbert Haider | Andrea Wobus
Journal: Molecules ISSN 1420-3049
Volume: 9; Issue: 10; Start page: 849; Date: 2004;
Keywords: Oxidative dehydrazination | pyridazine | indole | triazole.
Reaction of the title compound with hydrazine in the presence of air gives the 1-unsubstituted parent system via oxidative dehydrazination of the 1-hydrazino intermediate. The latter can be obtained in high yield by carrying out the hydrazinolysis step under inert gas, and it is smoothly converted into [1,2,4]-triazolo[4Ã¢Â€Â™,3Ã¢Â€Â™:1,6]pyridazino[4,5- b]indoles.