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Unexpected Hydrazinolysis Behaviour of 1-Chloro-4-methyl-5H-pyridazino[4,5-b]indole and a Convenient Synthesis of New [1,2,4]-Triazolo[4’,3’:1,6]pyridazino[4,5-b]indoles

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Author(s): Hussein El-Kashef | Abdelrahman A. H. Farghaly | Norbert Haider | Andrea Wobus

Journal: Molecules
ISSN 1420-3049

Volume: 9;
Issue: 10;
Start page: 849;
Date: 2004;
Original page

Keywords: Oxidative dehydrazination | pyridazine | indole | triazole.

ABSTRACT
Reaction of the title compound with hydrazine in the presence of air gives the 1-unsubstituted parent system via oxidative dehydrazination of the 1-hydrazino intermediate. The latter can be obtained in high yield by carrying out the hydrazinolysis step under inert gas, and it is smoothly converted into [1,2,4]-triazolo[4’,3’:1,6]pyridazino[4,5- b]indoles.
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