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Tularemia: A General Overview on Current Treatment Options

Author(s): Selçuk Kılıç | Murat Yeşilyurt

Journal: Klimik Journal
ISSN 1301-143X

Volume: 24;
Issue: 01;
Start page: 2;
Date: 2011;
Original page

Keywords: Tularemia | Francisella tularensis | therapeutics | prophylaxis | guidelines.

Tularemia is a zoonotic infection caused by Francisella tularensis with a worldwide distribution and diverse clinical manifestations. In humans, the disease varies from a localized illness to fulminant, life-threatening pneumonia or septicemia. For decades, streptomycin, gentamicin, and tetracycline have been used for the treatment of tularemia, but more recently, quinolones have been considered as acceptable alternatives. However, there are no randomized trials supporting the use of these antibiotics compared with each other. The increasing number of tularemia outbreaks in regions of Turkey outside the classic endemic areas in recent years has prompted renewed interest in this infectious disease. In this review, suggestions about treatment of tularemia are presented in the light of current literature.
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