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Toward a Library Synthesis of the Natural Dipeptide Antibiotic TAN 1057 A,B

Author(s): Nuria Aguilar | Jochen Krüger

Journal: Molecules ISSN 1420-3049
Volume: 7; Issue: 6; Start page: 469; Date: 2002;
Original page

Keywords: TAN 1057 A | B | dipeptide antibiotics | combinatorial chemistry

ABSTRACT
The natural dipeptide antibiotic TAN 1057 A,B represents a promising new antibiotic entity. In this communication we report a novel approach for the synthesis of TAN 1057 A,B analogs bearing variations in the β-arginine side chain. This approach involves a combination of liquid and solid phase methods and allows for a library synthesis of analogs of the natural product.