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Toward a Library Synthesis of the Natural Dipeptide Antibiotic TAN 1057 A,B

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Author(s): Nuria Aguilar | Jochen Krüger

Journal: Molecules
ISSN 1420-3049

Volume: 7;
Issue: 6;
Start page: 469;
Date: 2002;
Original page

Keywords: TAN 1057 A | B | dipeptide antibiotics | combinatorial chemistry

ABSTRACT
The natural dipeptide antibiotic TAN 1057 A,B represents a promising new antibiotic entity. In this communication we report a novel approach for the synthesis of TAN 1057 A,B analogs bearing variations in the β-arginine side chain. This approach involves a combination of liquid and solid phase methods and allows for a library synthesis of analogs of the natural product.
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