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Synthesis of Some New 4,5-Substituted-4H-1,2,4-triazole-3-thiol Derivatives

Author(s): M. Koparır | A. Cansız | A. Demirdağ

Journal: Molecules ISSN 1420-3049
Volume: 9; Issue: 4; Start page: 204; Date: 2004;
Original page

Keywords: 4H-1 | 2 | 4-triazole-3-thiols | azomethines | thiosemicarbazides.

ABSTRACT
In this study appropriate hydrazide compounds, furan-2-carboxylic acidhydrazide (1) and phenylacetic acid hydrazide (2) were converted into 1,4-substitutedthiosemicarbazides 4a-e and 5a-e and 4-amino-5-(furan-2-yl or benzyl)-4H-1,2,4-triazole-3-thiols 7 and 10. The 1,4-substituted thiosemicarbazides were then converted into5-(furan-2-yl or benzyl)-4-(aryl)-4H-1,2,4-triazole-3-thiols 8a-e and 9a-e. In addition, theazomethines 11a-d and 12a-d were prepared from the corresponding arylaldehydes and the4-amino-5-(furan-2-yl or benzyl)-4H-1,2,4-triazole-3-thiols 7 and 10. The structures of allthe synthesized compounds were confirmed by elemental analyses, IR, 1H-NMR and13 C-NMR spectra.