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Synthesis of Novel Quinazoline Derivatives via Pyrimidine ortho-Quinodimethane

Author(s): R. Chioua | F. Benabdelouahab | M. Chioua | R. Martínez-Alvarez | A. Herrera Fernández

Journal: Molecules ISSN 1420-3049
Volume: 7; Issue: 7; Start page: 507; Date: 2002;
Original page

Keywords: [4+2] Cycloaddition | Diels-Alder adduct | dimethyl 2 | 4-diphenylquinazoline dicarboxylate

ABSTRACT
The [4+2] cycloaddition between 2,4-diphenylpyrimidine ortho-quinodimethane and dimethyl acetylenedicarboxylate leads to 2,4-diphenylquinazoline-6,7-dicarboxylate (6). 2,4-Diphenylfuro[3,4-g]quinazoline-6,8-dione (7) is also obtained by basic hydrolysis of compound 6, followed by the closure of the resulting diacid in acetic anhydride.