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Synthesis of Novel Quinazoline Derivatives via Pyrimidine ortho-Quinodimethane

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Author(s): R. Chioua | F. Benabdelouahab | M. Chioua | R. Martínez-Alvarez | A. Herrera Fernández

Journal: Molecules
ISSN 1420-3049

Volume: 7;
Issue: 7;
Start page: 507;
Date: 2002;
Original page

Keywords: [4+2] Cycloaddition | Diels-Alder adduct | dimethyl 2 | 4-diphenylquinazoline dicarboxylate

ABSTRACT
The [4+2] cycloaddition between 2,4-diphenylpyrimidine ortho-quinodimethane and dimethyl acetylenedicarboxylate leads to 2,4-diphenylquinazoline-6,7-dicarboxylate (6). 2,4-Diphenylfuro[3,4-g]quinazoline-6,8-dione (7) is also obtained by basic hydrolysis of compound 6, followed by the closure of the resulting diacid in acetic anhydride.
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