Synthesis, Crystal Structure, Stacking Effect and Antibacterial Studies of a Novel Quaternary Copper (II) Complex with QuinoloneAuthor(s): Guangguo Wu | Guoping Wang | Xuchun Fu | Longguan Zhu
Journal: Molecules ISSN 1420-3049
Volume: 8; Issue: 2; Start page: 287; Date: 2003;
Keywords: Synthesis | crystal structure | stacking effect | antibacterial activity | copper complex | quinolone | ciprofloxacin | FT-IR Spectroscopy
The structural properties of a new copper (II) complex [Cu2(cip)2(bpy)2(pip)]Ã‚Â·6H2O (bpy=2,2Ã¢Â€Â™-bipyridyl, cip=1-cyclopropyl-6-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, pip= piperazinyl anion), obtained during the synthesis of the copper complex with ciprofloxacin (cpf), has been investigated. The complex crystallizes in the triclinic system, space group P-1. The cell dimensions are: a=6.874(2) ÃƒÂ…, b= 10.761(3) ÃƒÂ…, c= 17.969(5) ÃƒÂ…, ÃŽÂ± =80.071(6)Ã‚Â°, ÃŽÂ²= 85.253(6)Ã‚Â°, ÃŽÂ³=79.109(6)Ã‚Â°Ã¯Â¼ÂŒV=1284.5(6) ÃƒÂ…3, and Z=2. The Cu (II) ion displays a five-coordinate square pyramidal coordination with two nitrogen donors from bpy, the 4-keto and 3-carboxylate oxygen donors of cip, and the third nitrogen atom of the pip anion occupying the fifth site. There is a stack effect between cip ring and bpy ring from another molecule, where the stacking distance is about 3.5 ÃƒÂ…. The results of elemental analysis and FT-IR measurement are also included. Both ligand and complex were assayed against gram-positive and gram-negative bacteria by the doubling dilutions method. The complex shows the same minimal inhibitory concentration (MIC) against S. Aureus and E. Coli bacteria as the corresponding ligand.