Synthesis, Crystal Structure, and Conformation of Methyl 5-Oacetyl-5-cyano-6-deoxy-2,3-O-isopropylidene-ÃŽÂ²-L-gulofuranosideAuthor(s): JÃƒÂºlia MiÃ„ÂovÃƒÂ¡ | Bohumil Steiner | Miroslav KoÃƒÂ³Ã…Â¡ | JÃƒÂ¡n GajdoÃ…Â¡ | Vratislav Langer | Dalma GyepesovÃƒÂ¡
Journal: Molecules ISSN 1420-3049
Volume: 7; Issue: 5; Start page: 437; Date: 2002;
Keywords: Saccharide cyanohydrins | methyl 2 | 3-O-isopropylidene-ÃŽÂ²-L-gulofuranoside | Xray crystallography | conformation
Methyl 5-O-acetyl-5-cyano-6-deoxy-2,3-O-isopropylidene-ÃŽÂ²-L-gulofuranoside was prepared in high yield from methyl 6-deoxy-2,3-O-isopropylidene-ÃŽÂ±-D-lyxopentodialdo-1,4-furanoside. The configuration at the C5 atom was unambiguosly established by single crystal X-ray analysis of the corresponding 5-O-acetyl derivative. The conformation of the furanose and 1,3-dioxolane rings is also discussed.