Synthesis and Characterisation of Macrocyclic Diamino Chiral Crown EthersAuthor(s): Waldo H. Correa | Janet L. Scott
Journal: Molecules ISSN 1420-3049
Volume: 9; Issue: 6; Start page: 513; Date: 2004;
Keywords: Chiral diamino macrocycles | ether linked dialdehydes
A benign and efficient synthesis of chiral macrocyclic Ã¢Â€Â˜aza-crownÃ¢Â€Â™ ethers of varying ring size is reported. The synthesis involves a Schiff base condensation of ether linked dialdehydes of varying chain length and (1R,2R)-(Ã¢Â€Â“)-1,2-diaminocyclohexane under mild conditions to yield the macrocycles, which are subsequently reduced to yield the diamino analogues.