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A Synthesis of 6-(2,5-Dimethoxy-4-(2-aminopropyl)phenyl)-hexylthiol. A Ligand for Conjugation with Fluorescent Cadmium Selenide/Zinc Sulfide Core/Shell Nanocrystals and Biological Imaging

Author(s): Ian D. Tomlinson | Jesse L. Grey | Sandra J. Rosenthal

Journal: Molecules ISSN 1420-3049
Volume: 7; Issue: 11; Start page: 777; Date: 2002;
Original page

Keywords: Cadmium selenide / zinc sulfide / core/shells / 5HT2A / fluorescent imaging

ABSTRACT
The synthesis of 6-(2,5-dimethoxy-4-(2-aminopropyl)phenyl)hexylthiol, an agonist with a very high affinity for the 5HT2A serotonin receptor subtype is reported. This agonist was designed to be attached to highly fluorescent cadmium selenide/zinc sulfide core/shells via a thiol at the end of a linker arm. This conjugate has applications in biological assays and biological imaging.