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Syntheses of Quinazoline-2,4-dione Alkaloids and Analogues from Mexican Zanthoxylum Species â€

Author(s): I. A. Rivero | K. Espinoza | R. Somanathan

Journal: Molecules ISSN 1420-3049
Volume: 9; Issue: 7; Start page: 609; Date: 2004;
Original page

Keywords: Quinazoline-2 | 4-dione | alkaloids | triphosgene | anti-hypertensive activity.

ABSTRACT
Quinazolinone and quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties. In this paper we report the synthesis of ten quinazolinediones. The previous isolation of two of these compounds, namely 1-methyl-3-(2'-phenylethyl)-1H,3H-quinazoline-2,4-dione and 1-methyl-3-[2'-(4'- methoxyphenyl)ethyl]-lH,3H-quinazoline-2,4-dione, from the seed husks of Mexican Zanthoxylum species has been reported