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Structure-Activity Relationships for the 9-(Pyridin-2’-yl)- aminoacridines

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Author(s): Michael D. Mosher | Kristi L. Holmes | Katherine S. Frost

Journal: Molecules
ISSN 1420-3049

Volume: 9;
Issue: 3;
Start page: 102;
Date: 2004;
Original page

Keywords: Acridine | QSAR | pyridine | DNA.

ABSTRACT
A series of 9-(pyridin-2’-yl)-aminoacridines was prepared and analyzed for their ability to change the thermal denaturation temperature of genomic calf thymus DNA. Development of a QSAR equation indicated that electron withdrawing groups on the pyridine ring promoted the interaction with double stranded DNA.
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