Structure-Activity Relationships for the 9-(Pyridin-2Ã¢Â€Â™-yl)- aminoacridinesAuthor(s): Michael D. Mosher | Kristi L. Holmes | Katherine S. Frost
Journal: Molecules ISSN 1420-3049
Volume: 9; Issue: 3; Start page: 102; Date: 2004;
Keywords: Acridine | QSAR | pyridine | DNA.
A series of 9-(pyridin-2Ã¢Â€Â™-yl)-aminoacridines was prepared and analyzed for their ability to change the thermal denaturation temperature of genomic calf thymus DNA. Development of a QSAR equation indicated that electron withdrawing groups on the pyridine ring promoted the interaction with double stranded DNA.