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Structure-Activity Relationships for the 9-(Pyridin-2’-yl)- aminoacridines

Author(s): Michael D. Mosher | Kristi L. Holmes | Katherine S. Frost

Journal: Molecules ISSN 1420-3049
Volume: 9; Issue: 3; Start page: 102; Date: 2004;
Original page

Keywords: Acridine | QSAR | pyridine | DNA.

ABSTRACT
A series of 9-(pyridin-2’-yl)-aminoacridines was prepared and analyzed for their ability to change the thermal denaturation temperature of genomic calf thymus DNA. Development of a QSAR equation indicated that electron withdrawing groups on the pyridine ring promoted the interaction with double stranded DNA.