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The Role of Lymphostatin/EHEC Factor for Adherence-1 in the Pathogenesis of Gram Negative Infection

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Author(s): Jan-Michael A. Klapproth

Journal: Toxins
ISSN 2072-6651

Volume: 2;
Issue: 5;
Start page: 954;
Date: 2010;
Original page

Keywords: lymphocyte inhibitory factor A/EHEC factor for adherence-1 | lymphostatin | Gram negative bacterial toxin | Enteropathogenic E. coli | Enterohemorrhagic E. coli | immunosuppression | Citrobacter rodentium | intestinal epithelial barrier function

ABSTRACT
Lymphostatin/EHEC factor for adherence-1 is a novel large toxin represented in various Gram negative bacteria, highly associated with the development of infectious diarrhea and hemolytic uremic syndrome. In vitro and in vivo experiments identified lymphostatin/EFA-1 as a toxin with a central role in the pathogenesis of Gram negative bacteria, responsible for bacterial adhesion, intestinal colonization, immunosuppression, and disruption of gut epithelial barrier function.
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