Academic Journals Database
Disseminating quality controlled scientific knowledge

Role of clevidipine butyrate in the treatment of acute hypertension in the critical care setting: a review

ADD TO MY LIST
 
Author(s): Ahmed S Awad | Michael E Goldberg

Journal: Vascular Health and Risk Management
ISSN 1176-6344

Volume: 2010;
Issue: default;
Start page: 457;
Date: 2010;
Original page

ABSTRACT
Ahmed S Awad, Michael E GoldbergDepartment of Anesthesiology, Cooper University Hospital, UMDNJ-Robert Wood Johnson Medical School, Camden Campus, Camden, New Jersey, USAAbstract: Acutely elevated blood pressure in the critical care setting is associated with a higher risk of acute end-organ damage (eg, myocardial ischemia, stroke, and renal failure) and perioperative bleeding. Urgent treatment and careful blood pressure control are crucial to prevent significant morbidity. Clevidipine butyrate (Cleviprex™) is an ultrashort-acting, third-generation intravenous calcium channel blocker. It is an arterial-selective vasodilator with no venodilatory or myocardial depressive effects. Clevidipine has an extremely short half-life of approximately 1 minute as it is rapidly metabolized by blood and tissue esterases. These metabolites are then primarily eliminated through urine and fecal pathways. The rapid onset and the short duration of action permit tighter and closer adjustment of the blood pressure than is possible with other intravenous agents.Keywords: calcium channel blocker, antihypertensive medications, end-organ damage, hypertensive crisis, hypertensive urgency
Grammarly - world's best grammar checker