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Response to Comments of Peter G. Mantle

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Author(s): Gary G. Schwartz | Richard A. Manderville | Annie Pfohl-Leszkowicz

Journal: Toxins
ISSN 2072-6651

Volume: 2;
Issue: 10;
Start page: 2337;
Date: 2010;
Original page

Keywords: ochratoxin | testicular cancer | DNA adduct

ABSTRACT
The apparently high yield of testis tumors (25%) in rats exposed long-term to Ochratoxin A (OTA) is uninterpretable without data on tumor yield in unexposed rats. Conversely, our demonstration that prenatal exposure to OTA induces DNA adducts in the testes of newborn mice and the absence of these adducts in the testes of mice not exposed prenatally to OTA, is evidence for the presumptive carcinogenicity of OTA in the testis. Together with recent data showing that prenatal exposure to OTA depresses expression of DMRT1, a tumor suppressor gene in the testis, our findings suggest that OTA may be a cause of testicular cancer.
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