Reactivity of 3-Ethoxycarbonyl Isoquinolinium Salts Towards Various Nucleophilic Reagents: Applications to the Synthesis of New 1,2-Dihydroisoquinoline-3-carboxylatesAuthor(s): Mohamed Ameziane AÃƒÂ¯t Amer Meziane | Jean Pierre Bazureau
Journal: Molecules ISSN 1420-3049
Volume: 7; Issue: 2; Start page: 252; Date: 2002;
Keywords: 1 | 2-dihydro isoquinoline | lipophilic isoquinolinium | solvent-free quaternization | organolithium | alcoholate | N | O-acetal | domino reaction
Different types of novel 1,2-disubstituted 1,2-dihydro isoquinolines were synthesized by addition reactions of organolithium, alcoholates and borohydride reagents with various isoquinolinium salts. The leaving group character of the isoquinoline moiety was also evidenced.