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Reactivity of 3-Ethoxycarbonyl Isoquinolinium Salts Towards Various Nucleophilic Reagents: Applications to the Synthesis of New 1,2-Dihydroisoquinoline-3-carboxylates

Author(s): Mohamed Ameziane Aït Amer Meziane | Jean Pierre Bazureau

Journal: Molecules
ISSN 1420-3049

Volume: 7;
Issue: 2;
Start page: 252;
Date: 2002;
Original page

Keywords: 1 | 2-dihydro isoquinoline | lipophilic isoquinolinium | solvent-free quaternization | organolithium | alcoholate | N | O-acetal | domino reaction

Different types of novel 1,2-disubstituted 1,2-dihydro isoquinolines were synthesized by addition reactions of organolithium, alcoholates and borohydride reagents with various isoquinolinium salts. The leaving group character of the isoquinoline moiety was also evidenced.
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