Reactivity of 3-Ethoxycarbonyl Isoquinolinium Salts Towards Various Nucleophilic Reagents: Applications to the Synthesis of New 1,2-Dihydroisoquinoline-3-carboxylates
Author(s): Mohamed Ameziane Aït Amer Meziane | Jean Pierre BazureauJournal: Molecules ISSN 1420-3049
Volume: 7; Issue: 2; Start page: 252; Date: 2002;
Original page
Keywords: 1 | 2-dihydro isoquinoline | lipophilic isoquinolinium | solvent-free quaternization | organolithium | alcoholate | N | O-acetal | domino reaction
ABSTRACT
Different types of novel 1,2-disubstituted 1,2-dihydro isoquinolines were synthesized by addition reactions of organolithium, alcoholates and borohydride reagents with various isoquinolinium salts. The leaving group character of the isoquinoline moiety was also evidenced.
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