Quantum Chemical and Experimental Studies on the Mechanism of Alkylation of ÃŽÂ²-Dicarbonyl Compounds. The Synthesis of Five and Six Membered Heterocyclic Spiro DerivativesAuthor(s): Nurettin Sadikov | Sahin Nasibov | Cemil Ogretir | Halil Berber | Ali HÃƒÂ¼seyinli
Journal: Molecules ISSN 1420-3049
Volume: 9; Issue: 11; Start page: 922; Date: 2004;
Keywords: Alkylation of ÃŽÂ²-dicarbonyl compounds | spiro derivatives of barbituric acid | 2-chloro-1-(2- chloroethoxy)ethane | theoretical studies.
The alkylation of ÃŽÂ²-dicarbonyl compounds in a K2CO3/DMSO system wasfound to afford O- and C-alkylated derivatives, depending on the type of the ÃŽÂ²-dicarbonylcompound involved. The alkyl derivatives obtained were used in the synthesis of some newspiro barbituric acid derivatives. Quantum chemical calculations were carried out toelucidate the reaction mechanisms for some typical synthesis.