Preparation of Novel Selenopenams by Intramolecular Homolytic Substitution

Author(s): Michael W. Carland | Carl H. Schiesser

Journal: Molecules ISSN 1420-3049
Volume: 9; Issue: 6; Start page: 466; Date: 2004;
Original page

Keywords: Free radical | homolytic substitution | selenium | ÃŽÂ²-lactam.

ABSTRACT
Photolyses of the thiohydroximate ester derivatives 13 and 21 of the 4- (benzyl-seleno)-2-azetidinoines 7 and 20, afford the 1-aza-7-oxo-4-selenabicyclo- [3.2.0]heptane ring systems 14 and 21 in good to moderate yield in processes that presumably involve intramolecular homolytic substitution at selenium with expulsion of benzyl radical. Extension of this methodology to the preparation of derivatives 24 of 12,2a-dihydro-1H,8H-azeto[2,1-b][1,3]benzoselenazin-1-one (22) is also described.

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