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The Preparation of Fluorescence-Quenched Probes for Use in the Characterization of Human Factor Xa Substrate Binding Domains

Author(s): Karen M. Bromfield | Julia Cianci | Peter J. Duggan

Journal: Molecules ISSN 1420-3049
Volume: 9; Issue: 6; Start page: 427; Date: 2004;
Original page

Keywords: Solid phase peptide synthesis | parallel synthesis | fluorescence-quenched substrates | protease | factor Xa.

ABSTRACT
The preparation and characterization by LCMS of a library of 55 fluorescence- quenched peptides is described. The peptides bear a terminal anthranilamide fluorophore and a penultimate 2,4-dinitrophenyl-L-lysine quencher, and will be used to probe the substrate binding domain of the human blood coagulation enzyme, factor Xa.