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NetB, a Pore-Forming Toxin from Necrotic Enteritis Strains of Clostridium perfringens

Author(s): Anthony L. Keyburn | Trudi L. Bannam | Robert J. Moore | Julian I. Rood

Journal: Toxins ISSN 2072-6651
Volume: 2; Issue: 7; Start page: 1913; Date: 2010;
Original page

Keywords: NetB | necrotic enteritis | Clostridium perfringens | pore-forming toxin

ABSTRACT
The Clostridium perfringens necrotic enteritis B-like toxin (NetB) is a recently discovered member of the β-barrel pore-forming toxin family and is produced by a subset of avian C. perfringens type A strains. NetB is cytotoxic for avian cells and is associated with avian necrotic enteritis. This review examines the current state of knowledge of NetB: its role in pathogenesis, its distribution and expression in C. perfringens and its vaccine potential.