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Monitoring Radiographic Brain Tumor Progression

Author(s): Ankit I. Mehta | Charles W. Kanaly | Allan H. Friedman | Darell D. Bigner | John H. Sampson

Journal: Toxins ISSN 2072-6651
Volume: 3; Issue: 3; Start page: 191; Date: 2011;
Original page

Keywords: glioblastoma | radiographic progression | tumor progression | MRI

ABSTRACT
Determining radiographic progression in primary malignant brain tumors has posed a significant challenge to the neuroncology community. Glioblastoma multiforme (GBM, WHO Grade IV) through its inherent heterogeneous enhancement, growth patterns, and irregular nature has been difficult to assess for progression. Our ability to detect tumor progression radiographically remains inadequate. Despite the advanced imaging techniques, detecting tumor progression continues to be a clinical challenge. Here we review the different criteria used to detect tumor progression, and highlight the inherent challenges with detection of progression.