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A Method for Synthesizing Partially Substituted Cucurbit[n]uril

Author(s): Anthony I. Day | Alan P. Arnold | Rodney J. Blanch

Journal: Molecules
ISSN 1420-3049

Volume: 8;
Issue: 1;
Start page: 74;
Date: 2003;
Original page

Keywords: Macrocycles | molecular binding | partially substituted

A novel approach to cucurbituril synthesis is described where partial substitution is introduced into cucurbit[n]uril. The identification of homologues (and their substitution) in reaction mixtures is achieved by a combination of ESMS and the use of the molecular probes (guests) 1,4-dioxane and 1,9-octanediamine. A unique symmetrical hexamethylcucurbit[3,3]uril, the major product, was isolated and characterized.