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Mechanisms of Cisplatin Nephrotoxicity

Author(s): Ronald P. Miller | Raghu K. Tadagavadi | Ganesan Ramesh | William Brian Reeves

Journal: Toxins ISSN 2072-6651
Volume: 2; Issue: 11; Start page: 2490; Date: 2010;
Original page

Keywords: cisplatin | inflammation | kidney injury | nephrotoxicity | apoptosis | dendritic cells | cytokines | toll-like receptors

ABSTRACT
Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin-induced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.