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Mechanical tuning of molecular machines for nucleotide recognition at the air-water interface

Author(s): Mori Taizo | Okamoto Ken | Endo Hiroshi | Sakakibara Keita | Hill Jonathan | Shinoda Satoshi | Matsukura Miki | Tsukube Hiroshi | Suzuki Yasumasa | Kanekiyo Yasumasa | Ariga Katsuhiko

Journal: Nanoscale Research Letters
ISSN 1931-7573

Volume: 6;
Issue: 1;
Start page: 304;
Date: 2011;
Original page

Abstract Molecular machines embedded in a Langmuir monolayer at the air-water interface can be operated by application of lateral pressure. As part of the challenge associated with versatile sensing of biologically important substances, we here demonstrate discrimination of nucleotides by applying a cholesterol-armed-triazacyclononane host molecule. This molecular machine can discriminate ribonucleotides based on a twofold to tenfold difference in binding constants under optimized conditions including accompanying ions in the subphase and lateral surface pressures of its Langmuir monolayer. The concept of mechanical tuning of the host structure for optimization of molecular recognition should become a novel methodology in bio-related nanotechnology as an alternative to traditional strategies based on increasingly complex and inconvenient molecular design strategies.
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