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Impact of Early Ribavirin Use on Fatality Among the Patients with Crimean-Congo Haemorrhagic Fever

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Author(s): Saliha Bakır-Özbey

Journal: Klimik Journal
ISSN 1301-143X

Volume: 23;
Issue: 01;
Start page: 6;
Date: 2010;
Original page

Keywords: Crimean-Congo haemorrhagic fever | epidemiology | clinical features | laboratory features

ABSTRACT
Objective: Crimean-Congo haemorrhagic fever (CCHF) is a potentially fatal zoonotic disease. It is mostly encountered in the northeastern part of Turkey, mainly in Tokat, Sivas, Yozgat, Çorum and Erzurum provinces. Methods: In this study, clinical, laboratory and epidemiological features of 85 CCHF cases diagnosed between May 2008-September 2009 in Kastamonu were evaluated retrospectively. Results: The mean age of the patients was 51±16 years. The male to female ratio was 0.8. Regarding possible modes of transmission, 80% of the cases had a history of tick bite, 90.5% worked in animal husbandry or farms. The time of onset of disease was 3.2±1.9 days after the tick-bite. Weakness (96.4%) and high fever (94.1%) were the most common symptoms, while in the physical examination rash (17.6%), conjunctival injection and facial redness (9.4%) and hyperemic pharynx (7%) were observed. Laboratory results yielded thrombocytopenia in 97.6%, leukopenia in 88.2%, elevated transaminase levels in 70.5% and anemia in 35.2% of the patients. Thirty eight cases whose clinical status deteriorated rapidly and with platelet counts of
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