Immobilization of 1-[N-(M-Nitrobenzoyl)-ÃŽÂ±-D,L-Asparagyl]-2-Benzylbenzimidazole on GellanAuthor(s): Marcel Popa | Valeriu Ã…Âžunel | LÃ„ÂƒcrÃ„Âƒmioara BÃ„ÂƒlÃ„ÂƒiÃ…Â£Ã„Âƒ Rusu
Journal: Molecules ISSN 1420-3049
Volume: 8; Issue: 3; Start page: 297; Date: 2003;
Keywords: Gellan | polymer-drug system | controlled release
This paper studies the dicyclohexylcarbodiimide activated coupling reaction through ester-type covalent bonds of an oxazolone derived from N-(m-nitrobenzoyl)-L-asparagic acid, ring opened with 2-benzylbenzimidazole, on gellan. Based on a centered, rotatory, composed, second order experimental design, the regression equation describing the dependence of the amount of drug chemically bonded to the support on the reaction parameters is obtained. The efficiency of the coupling reaction over the variation domain established is maximum when the parametersÃ¢Â€Â™ highest values are used. The kinetics of the drugÃ¢Â€Â™s release from the support are studied under alkaline hydrolysis conditions.