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Immobilization of 1-[N-(M-Nitrobenzoyl)-α-D,L-Asparagyl]-2-Benzylbenzimidazole on Gellan

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Author(s): Marcel Popa | Valeriu Şunel | Lăcrămioara Bălăiţă Rusu

Journal: Molecules
ISSN 1420-3049

Volume: 8;
Issue: 3;
Start page: 297;
Date: 2003;
Original page

Keywords: Gellan | polymer-drug system | controlled release

ABSTRACT
This paper studies the dicyclohexylcarbodiimide activated coupling reaction through ester-type covalent bonds of an oxazolone derived from N-(m-nitrobenzoyl)-L-asparagic acid, ring opened with 2-benzylbenzimidazole, on gellan. Based on a centered, rotatory, composed, second order experimental design, the regression equation describing the dependence of the amount of drug chemically bonded to the support on the reaction parameters is obtained. The efficiency of the coupling reaction over the variation domain established is maximum when the parameters’ highest values are used. The kinetics of the drug’s release from the support are studied under alkaline hydrolysis conditions.
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