Bilingual day care in Zurich Kinderkrippe Zürich
Kinderbetreuung in Zürich Kinderkrippe Zürich
Kita in Zürich Kinderkrippe Zürich
Kinderkrippe in Zürich Seebach Kinderkrippe Seebach
Academic Journals Database
disseminating
quality controlled scientific knowledge



Heat-Labile Enterotoxin: Beyond G M1 Binding

Author(s): Benjamin Mudrak | Meta J. Kuehn

Journal: Toxins ISSN 2072-6651
Volume: 2; Issue: 6; Start page: 1445; Date: 2010;
Original page

Keywords: heat-labile enterotoxin | ETEC | GM1 | lipopolysaccharide | blood antigen

ABSTRACT
Enterotoxigenic Escherichia coli (ETEC) is a significant source of morbidity and mortality worldwide. One major virulence factor released by ETEC is the heat-labile enterotoxin LT, which is structurally and functionally similar to cholera toxin. LT consists of five B subunits carrying a single catalytically active A subunit. LTB binds the monosialoganglioside GM1, the toxin’s host receptor, but interactions with A-type blood sugars and E. coli lipopolysaccharide have also been identified within the past decade. Here, we review the regulation, assembly, and binding properties of the LT B-subunit pentamer and discuss the possible roles of its numerous molecular interactions.