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Fused Heterocycles: Synthesis of Some New Imidazo[1,2-a]- pyridine Derivatives

Author(s): Birgul Ozden Kasimogullari | Zafer Cesur

Journal: Molecules
ISSN 1420-3049

Volume: 9;
Issue: 10;
Start page: 894;
Date: 2004;
Original page

Keywords: Imidazo[1 | 2-a]pyridine | hydrazones | thiazolidines | spirothiazolidines | antituberculous activity.

Some new thiazolidines and spirothiazolidines derived from hydrazones of2-methylimidazo[1,2-a]pyridine-3-carboxylic acid hydrazide, a bioisosteric derivative ofisoniazid, were synthesized and characterized by analytical, IR, 1H- and 13C-NMR andmass spectral data. Some of the newly synthesized compounds were screened for theirantimycobacterial activities. None of the tested compounds showed significant in vitroantituberculous activity at 6.25 μg/mL (MIC rifampin 0.031 μg/mL).