Fused Heterocycles: Synthesis of Some New Imidazo[1,2-a]- pyridine DerivativesAuthor(s): Birgul Ozden Kasimogullari | Zafer Cesur
Journal: Molecules ISSN 1420-3049
Volume: 9; Issue: 10; Start page: 894; Date: 2004;
Keywords: Imidazo[1 | 2-a]pyridine | hydrazones | thiazolidines | spirothiazolidines | antituberculous activity.
Some new thiazolidines and spirothiazolidines derived from hydrazones of2-methylimidazo[1,2-a]pyridine-3-carboxylic acid hydrazide, a bioisosteric derivative ofisoniazid, were synthesized and characterized by analytical, IR, 1H- and 13C-NMR andmass spectral data. Some of the newly synthesized compounds were screened for theirantimycobacterial activities. None of the tested compounds showed significant in vitroantituberculous activity at 6.25 ÃŽÂ¼g/mL (MIC rifampin 0.031 ÃŽÂ¼g/mL).