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From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules

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Author(s): Adak Nasiripourdori | Valérie Taly | Thomas Grutter | Antoine Taly

Journal: Toxins
ISSN 2072-6651

Volume: 3;
Issue: 3;
Start page: 260;
Date: 2011;
Original page

Keywords: nAChR | P2X | GABA | Glycine | Serotonin | NMDA | AMPA | Kainate

ABSTRACT
Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the target of plant and animal toxins. Together this makes toxin/receptor interactions important to drug discovery projects. Therefore, toxins acting on LGIC are presented and their current/potential therapeutic uses highlighted.
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