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From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules

Author(s): Adak Nasiripourdori | Valérie Taly | Thomas Grutter | Antoine Taly

Journal: Toxins ISSN 2072-6651
Volume: 3; Issue: 3; Start page: 260; Date: 2011;
Original page

Keywords: nAChR | P2X | GABA | Glycine | Serotonin | NMDA | AMPA | Kainate

ABSTRACT
Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the target of plant and animal toxins. Together this makes toxin/receptor interactions important to drug discovery projects. Therefore, toxins acting on LGIC are presented and their current/potential therapeutic uses highlighted.