Academic Journals Database
Disseminating quality controlled scientific knowledge

An Efficient Preparation of 1,2-Diamino-1-phenylheptane

ADD TO MY LIST
 
Author(s): S. Thennarasu | P. T. Perumal

Journal: Molecules
ISSN 1420-3049

Volume: 7;
Issue: 6;
Start page: 487;
Date: 2002;
Original page

Keywords: Piperidinone | Schmidt rearrangement | Hexahydrodiazapinone | Vicinal diamine

ABSTRACT
A convenient four-step method for the preparation of the lipophilic vicinal diamine 1,2-diamino-1-phenylheptane is described. Condensation involving octan-2-one, benzaldehyde and ammonia is reported. Regioselective Schmidt rearrangement of 2,6-diphenyl-3-pentyl-piperidin-4-one (1) to 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one (3) is presented. Hydrolysis of 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one to 1,2-diamino-1-phenylheptane (4) is also reported for the first time.
Get a faster system with an easy scan today!