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Effects of Radix Ginseng and Radix Notoginseng formula on expressions of vascular endothelial growth factor receptor-2 and hypoxia-inducible factor-1α in ischemic myocardium of rats with acute myocardial infarction

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Author(s): Xue-jun DU

Journal: Zhong Xi Yi Jie He Xue Bao
ISSN 1672-1977

Volume: 8;
Issue: 6;
Start page: 548;
Date: 2010;
Original page

Keywords: Radix Ginseng | Radix Notoginseng | vascular endothelial growth factor receptor-2 | hypoxia-inducible factor-1α | myocardial ischemia | rats

ABSTRACT
Objective: To investigate the effects of Radix Ginseng and Radix Notoginseng formula on expressions of vascular endothelial growth factor receptor-2 (VEGFR-2) and hypoxia-inducible factor-1α (HIF-1α) in ischemic myocardium of rats with acute myocardial infarction. Methods: A total of 100 Wistar rats were randomly divided into normal control group, sham-operated group, untreated group, metoprolol (Betaloc) group, and high- and low-dose Radix Ginseng and Radix Notoginseng formula groups. Acute myocardial infarction was induced in the untreated group, Betaloc group, and high- and low-dose Radix Ginseng and Radix Notoginseng formula groups by left anterior descending coronary artery ligation. After 12-day treatment, microvessel density (MVD) in ischemic myocardium was detected by immunohistochemical method, while expressions of VEGFR-2 and HIF-1α proteins were detected by Western blotting, and expressions of VEGFR-2 and HIF-1α mRNAs were detected by real-time fluorescent quantitative polymerase chain reaction. Results: MVD in the untreated group was increased significantly, higher than those in the normal control group and the sham-operated group (P
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