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Effects of honey on inflammation and nitric oxide production in Wistar rats

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Author(s): Bamidele Victor Owoyele

Journal: Zhong Xi Yi Jie He Xue Bao
ISSN 1672-1977

Volume: 9;
Issue: 4;
Start page: 447;
Date: 2011;
Original page

Keywords: honey | inflammation | nitric oxide | rats

ABSTRACT
Objective: The aim of the study is to investigate the effects of honey on acute and chronic inflammations and nitric oxide production in rats. Methods: Carrageenan, cotton pellet and formaldehyde methods were used in quantifying the anti-inflammatory effect of honey while the effect of honey on nitric oxide (NO) production was investigated by administering NG-nitro-L-arginine methyl ester (L-NAME, 100 mg/kg body weight, subcutaneously) and L-arginine (300 mg/kg body weight, intraperitoneally) to groups of rats. Animals were divided into five groups each comprising of five rats in each experiment; two groups were orally administered distilled water (control) and indomethacin (5 mg/kg body weight), respectively, while the remaining three groups were administered 2, 6 and 10 g/kg honey for anti-inflammatory studies. Results: Honey significantly (P
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