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Effect of anesthetics on gastric damage using two models of portal hypertension

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Author(s): Paula RS Câmara | Gisele P Moi | José Geraldo P Ferraz | José Murilo R Zeitune

Journal: World Journal of Gastrointestinal Pharmacology and Therapeutics
ISSN 2150-5349

Volume: 1;
Issue: 4;
Start page: 81;
Date: 2010;
Original page

Keywords: Sodium pentobarbitone | Portal hypertension | Cirrhosis | Gastric damage | Ketamine/xylazine

ABSTRACT
AIM: To investigate the effect of sodium pentobarbitone (SP) or ketamine/xylazine (KX) anesthetics on acute gastric injury.METHODS: Portal hypertension was induced by bile duct ligation (BDL) or portal vein stenosis (PVS). Ethanol (EtOH)-induced gastric damage was assessed using ex vivo gastric chamber experiments. Gastric blood flow (GBF) was also measured by laser doppler flowmetry.RESULTS: EtOH-induced gastric damage was reduced in BDL rats under KX anesthesia in comparison to those under SP anesthesia. GBF dysfunction in fasted BDL rats was partially restored under KX anesthesia. In contrast, in fasted PVS rats, EtOH-induced gastric damage was increased under KX anesthesia while GBF was reduced.CONCLUSION: The use of KX anesthesia in experimental procedures involving cirrhotic rats (but not those with pure portal hypertension) is preferable to SP anesthesia.
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