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Development of Treatment Concepts for the Use of Botulinum Toxin A in Children with Cerebral Palsy

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Author(s): Richard Placzek | Dagmar Siebold | Julia F. Funk

Journal: Toxins
ISSN 2072-6651

Volume: 2;
Issue: 9;
Start page: 2258;
Date: 2010;
Original page

Keywords: botulinum toxin A | cerebral palsy | CP | multi-level treatment | key-muscle concept

ABSTRACT
The treatment of children with cerebral palsy with Botulinum toxin A injections is well established, safe and effective. However, a standardized injection strategy is still missing and the used dosage has escalated over the years. In the recent past, the recommended dosages in Europe were, however, reduced due to a better understanding of the relationship between dosage, severe side effects and the kind of anesthesia used. To combine safety and efficacy, the trend tends to a lower dosage, but combined with a more specific selection of injected muscles. The treatment of these key-muscles takes into account the best support for motor development to attain each individual motor milestone.
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