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Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach

Author(s): Jie Shi | Mei-Yu Geng | Chang-Xiao Liu

Journal: Molecules
ISSN 1420-3049

Volume: 9;
Issue: 11;
Start page: 978;
Date: 2004;
Original page

Keywords: Cocktail approach | enzymes | drug safety evaluation.

The sex-based differences between the effects of two novel sugar-based drug candidates, a sulfated polymannuroguluronate (SPMG-911) and an acidic oligosaccharide sugar chain compound (AOSC-971), on the enzymes CYP 1A2 and CYP 2E1 were investigated. The results showed that neither SPMG-911 nor AOSC-971 have any effect on CYP1A2, while AOSC-971 induced the CYP 2E1 in male rats. The results are useful for their safety evaluation, as well as for the prediction of inter-drug interactions associated with the two drugs.
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