Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a Ã¢Â€ÂœCocktailÃ¢Â€Â ApproachAuthor(s): Jie Shi | Mei-Yu Geng | Chang-Xiao Liu
Journal: Molecules ISSN 1420-3049
Volume: 9; Issue: 11; Start page: 978; Date: 2004;
Keywords: Cocktail approach | enzymes | drug safety evaluation.
The sex-based differences between the effects of two novel sugar-based drug candidates, a sulfated polymannuroguluronate (SPMG-911) and an acidic oligosaccharide sugar chain compound (AOSC-971), on the enzymes CYP 1A2 and CYP 2E1 were investigated. The results showed that neither SPMG-911 nor AOSC-971 have any effect on CYP1A2, while AOSC-971 induced the CYP 2E1 in male rats. The results are useful for their safety evaluation, as well as for the prediction of inter-drug interactions associated with the two drugs.