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Botulinum Neurotoxin for Pain Management: Insights from Animal Models

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Author(s): Flaminia Pavone | Siro Luvisetto

Journal: Toxins
ISSN 2072-6651

Volume: 2;
Issue: 12;
Start page: 2890;
Date: 2010;
Original page

Keywords: botulinum toxin | SNARE | pain | animal model | analgesia | inflammatory pain | chronic pain | peripheral sensitization | central sensitization | retrograde axonal transport

ABSTRACT
The action of botulinum neurotoxins (BoNTs) at the neuromuscular junction has been extensively investigated and knowledge gained in this field laid the foundation for the use of BoNTs in human pathologies characterized by excessive muscle contractions. Although much more is known about the action of BoNTs on the peripheral system, growing evidence has demonstrated several effects also at the central level. Pain conditions, with special regard to neuropathic and intractable pain, are some of the pathological states that have been recently treated with BoNTs with beneficial effects. The knowledge of the action and potentiality of BoNTs utilization against pain, with emphasis for its possible use in modulation and alleviation of chronic pain, still represents an outstanding challenge for experimental research. This review highlights recent findings on the effects of BoNTs in animal pain models.