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Alzheimer's disease and Type 2 diabetes mellitus: the cholinesterase connection?

Author(s): Allam Appa Rao | Sridhar Gumpeny | Thota Hanuman | Suresh Babu Changalasetty | Siva Prasad Akula | Divakar Ch

Journal: Lipids in Health and Disease ISSN 1476-511X
Volume: 5; Issue: 1; Start page: 28; Date: 2006;
Original page

ABSTRACT
Abstract Alzheimer's disease and type 2 diabetes mellitus tend to occur together. We sought to identify protein(s) common to both conditions that could suggest a possible unifying pathogenic role. Using human neuronal butyrylcholinesterase (AAH08396.1) as the reference protein we used BLAST Tool for protein to protein comparison in humans. We found three groups of sequences among a series of 12, with an E-value between 0–12, common to both Alzheimer's disease and diabetes: butyrylcholinesterase precursor K allele (NP_000046.1), acetylcholinesterase isoform E4-E6 precursor (NP_000656.1), and apoptosis-related acetylcholinesterase (1B41|A). Butyrylcholinesterase and acetylcholinesterase related proteins were found common to both Alzheimer's disease and diabetes; they may play an etiological role via influencing insulin resistance and lipid metabolism.